Targeted therapy for advanced melanoma blocks the activity of certain molecules within cancer cells that control cell growth. Two such drugs, dabrafenib (Tafinlar) and trametinib (Mekinist), shrink tumors and help patients with advanced melanoma live longer.
Through clinical trials, cancer researchers have found that combining dabrafenib and trametinib can treat advanced melanoma more effectively than either medication on its own. The combination also produces less serious side effects than the single drugs used alone.
Dabrafenib is a BRAF (pronounced bee-raff) inhibitor, and trametinib is a MEK (pronounced meck) inhibitor. Both medications:
Learn more about dabrafenib (Tafinlar) and trametinib (Mekinist) as separate drugs.
Dabrafenib blocks the activity of a mutated version of a molecule called BRAF. Trametinib blocks the activity of an enzyme molecule called MEK. Both BRAF and MEK are key molecules that help regulate cell growth.
Certain mutations in BRAF signal cells to develop abnormally and divide out of control. These cells can grow into a melanoma tumor. About half of all melanomas have a BRAF mutation.
MEK receives signals from BRAF and other molecules in the cell. Scientists have found that blocking MEK alone is not as effective as blocking BRAF and MEK at the same time.
The combination of dabrafenib and trametinib blocks the signaling pathway of the abnormal BRAF molecules. This action slows or stops the out-of-control cell growth:
In 2014, the FDA approved the use of dabrafenib in combination with trametinib to treat patients who have advanced stages of melanoma:
Dabrafenib with trametinib as combination therapy works only in patients whose melanoma has tested positive for the BRAF V600E or V600K mutation. If you have advanced melanoma, your physician will test you for specific genetic mutations before prescribing this medication combination. The physician will send a biopsy (sample of cancer tissue removed from your body) to a special lab for analysis.
Patients take both medications orally (swallowing by mouth).
The combination of dabrafenib and trametinib targets specific molecules that regulate cancer cell growth, with the goals of :
Results from two Phase III clinical trials in 2014 showed improved patient outcomes for patients taking dabrafenib and trametinib compared with:
Melanoma treatments, like dabrafenib and trametinib, have side effects, which can sometimes be serious. Patients should talk with their physician to learn more about the side effects of these and other melanoma treatment options.
Not all treatments work for all patients with melanoma because everyone is different. If you are interested in learning more about the combination of dabrafenib and trametinib, here are some questions you should ask your physicians:
Patient Assistant Programs (PAPs) are designed so that you still have access to the treatments you need, in any financial circumstance. Learn more about the manufacturer’s patient assistance program and other options here.
Manufacturer’s Patient Assistance
Latest Treatments for Advanced Melanoma
Learn more about the latest, most effective treatments for patients who have advanced melanoma:
The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $131 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $415 million in outside funds for research. Learn more about our funded research.